CYTOSKELETON

Cytoskeleton Products (click for new additions to this section)

ACTIN

T-108
Cytochalasin B
98%, MW=479.6 [14930-96-2] Storage: -20°C
Cytochalasin B is a cell permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It also inhibits monosaccharide transport across cell membranes³.
5 mg
5 x 5 mg

T-109
Cytochalasin D
98%, MW=507.6 [22144-77-0] Storage: -20°C
Cytochalasin D is a cell permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes^1-4.
1 mg
5 x 1 mg

T-110
Latrunculin B
98%, MW=395.5 [76343-94-7] Storage: -20°C
Latrunculin B is a structurally unique marine toxin isolated from the Red Sea sponge Latrunculia magnifica. It inhibits actin polymerization⁵ and disrupts microfilament organization⁶ as well as microfilament-mediated processes^7,8 and is 10 to 100-fold more potent than the cytochalasins^6,9.
1 mg
5 x 1 mg

T-111
Phalloidin
>95%, MW=788.9 [17466-45-4] Storage: -20°C
Phalloidin is a toxic bicyclic peptide isolated from Amanita phalloides. It is a potent and specific stabilizer of F-actin¹.
1 mg
5 x 1 mg

MICROTUBULES

T-118
Colchicine
98%, MW=399.4 [64-86-8] Storage: RT
Depolymerizes microtubules and inhibits tubulin polymerization¹⁰. Induces apoptosis in a variety of cell lines^11,12.
1 g

T-101
Nocodazole (R 17934)
Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl]-carbamate
99%, MW=301.3 [31430-18-9] Storage: RT
Microtubule inhibitor^13,14.
10 mg
50 mg

T-104
Taxol
>98%, MW=853.9 [33069-62-6] Storage: -20°C
Antitumor agent isolated from the bark of the Pacific Yew tree (Taxus brevifolia)^15,16,17. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin¹⁸. It inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells¹⁹.
5 mg
25 mg
250 mg
NEW LOWER PRICE

T-102
Tubulozole-C (R 46846)
99%, MW=544.9 [84697-22-3] Storage: RT
Inhibits tubulin polymerization^20,21.
10 mg
100 mg

T-103
Tubulozole-T (R 64181)
99%, MW=544.9 [95480-32-3] Storage: RT
Inactive trans-isomer of tubulozole C.
10 mg
100 mg

T-116
Vinblastine Sulfate
98%, MW=909.1 [143-67-9] Storage: -20?br> Inhibits normal microtubule assembly and causes aberrant tubulin polymerization¹⁰. Induces apoptosis²². Cancer chemotherapeutic agent²³.
10 mg
50 mg

T-117
Vincristine Sulfate
99%, MW=923.0 [2068-78-2] Storage: -20?br> Inhibits normal microtubule assembly and causes aberrant tubulin polymerization¹⁰. Induces apoptosis²⁴. Cancer chemotherapeutic agent²³.
5 mg
25 mg

REFERENCES

1. J.A. Cooper J. Cell Biol. 1987 105 1473

2. M.D. Flanagan and S. Li J. Biol. Chem. 1980 255 835

3. D.W. Goddette and C. Freiden J. Biol. Chem. 1986 261 15974

4. M. Shliwa J. Cell Biol. 1982 92 79

5. M. Coue et al. FEBS Lett. 1987 213 316

6. I. Spector et al. Cell Motil. Cytoskeleton 1989 13 127

7. C.A. de Oliveira and B. Mantovani Life Sci. 1988 43 1825

8. G. Schatten et al. Exp. Cell Res. 1986 166 191

9. I. Spector et al. Science 1983 219 493

10. E. Hamel. Med. Res. Rev. 1996 16 207

11. E. Bonfoco et al. Exp. Cell Res. 1995 218 189

12. L. Lindenboim et al. J. Neurochem. 1995 64 1054

13. M. De Brabander et al. Cell Motility 1980 1 469

14. J. Hoebeke et al. Biochem. Biophys. Res. Commun. 1976 69 319

15. W.P. McGuire et al. Ann. Int. Med. 1989 111 273

16. A.H. Ding et al. Science 1990 248 370

17. M.M. and J.B. Tucker J. Cell Sci. 1990 97 101

18. P.C. Letourneau and A.H. Ressler J. Cell Biol. 1984 98

19. R. Danesi et al. Mol. Pharmacol. 1995 47 1106

20. R. Van Ginckel et al. Eur. J. Cancer Clin. Oncol. 1984 20 99

21. G.M.A. Geuens et al. Cancer Res. 1985 45 733

22. V.L. Gabai e t al. FEBS Lett. 1995 375 21

23. R.H. Himes Pharmac. Ther. 1991 51 257

24. J. Zhang et al. Proc. Natl. Acad. Sci. USA 1996 93 5325