TWC BioSearch
Signal Transduction Supplier
New Product Addendum
APOPTOSIS
SE-760
Casputin™ Reagent
Casputin™ Reagent contains a recombinant, chimaeric protein which incorporates BIRs 2
and 3 (Baculovirus IAP Repeats) from XIAP/hILP/MIHA. Casputin™
is a potent inhibitor of caspase-3 (CPP32/Yama/Apopain), but has little or no effect on
caspase-8 (FLICE/Mch5/MACH) or caspase-1 (ICE). It is only marginally inhibitory to
caspase-10 (Mch4).
250 µg
R. Takahashi et al. J. Biol. Chem. 1998 273
7787
Q.L. Deveraux et al. Nature 1997 388 300
C.S. Duckett et al. EMBO J. 1996 15 2685 [
A.G. Uren et al. Proc. Natl. Acad. Sci. U S A 1996 93 4974
SE-721
Soluble TRAIL (Apo2L; human, recombinant)
>95%, 23kDa, Storage -80°C
TRAIL, also called Apo2L, is a member of the tumor
necrosis factor family (TNF). In contrast to other family members such as TNFa/TNFR1 and FasL/Fas, TRAIL and
its receptors DR4 and DR5 are widely expressed in many human tissues. TRAIL activates
rapid apoptosis in many transformed cell lines but not in normal tissues, even though
TRAIL and its receptors DR4 and DR5 are expressed on both cell types. Evidence shows a
glycophospholipid-anchored cell surface protein designated decoy receptor 1 (DcR1 or TRID)
acts as a decoy to inhibit TRAIL signaling. Thus, study of TRAIL and its signaling
pathways may have direct applications in selective tumor cell death and cancer research.
100 µg
G. Pan et al. Science 1997 276 111
G. Pan et al. Science 1997 277 815
J. P. Sheridan et al. Science 1997 277 818
CASPASE-3
ASSAY KITS
Caspase-3 (also known as CPP32, apopain and Yama) is a member of the interleukin-1
b converting enzyme (ICE) family
of cysteine proteases. The enzyme is composed of a 17 and 12 kDa subunits derived from a
common proenzyme, pro-caspase-31,2,3.
The caspase-3 is activated during apoptotic signalling events by upstream proteases
including caspase-6, caspase-8 (FLICE)4 and cytotoxic
T-cell-derived granzyme B5. Targets of caspase-3 cleavage
include poly(ADP-ribose) polymerase (PARP)6, nuclear lamins7 and others.
BIOMOL QuantiZyme™ Assay System
AK-703
CASPASE-3 Cellular Activity Assay Kit PLUS
The CASPASE-3 Cellular Activity Assay Kit PLUS is a complete assay system to
measure endogenous caspase-3 protease activity in cell extracts plus it includes
purified caspase-3 (human, recombinant) as a reference material! It employs the
colorimetric substrate DEVD-p-nitroanilide which upon cleavage has increased absorption at
405nm. The assays are performed in a convenient 96-well microplate format. The kit is
useful for screening cell-permeable inhibitors of caspase-3, a potential therapeutic
target8. An inhibitor, Ac-DEVD-CHO (aldehyde), is also
included as a control1.
The assay is simple and direct. Cell cultures are induced to undergo apoptosis under
the desired experimental conditions. Cells are lysed with CELL LYSIS BUFFER, and a sample
of the homogenate is added to a 96-well microtiter plate containing substrate and buffer.
The increase in absorption is monitored at 405nm, and specific activity of caspase-3 is
calculated in conjuction with the supplied controls and reagents. Purified caspase-3
(enough for 10 assays) is also included as a control reference and for experimentation.
This kit contains enough reagents to perform 96 assays, and is a great value!
1 kit (96 well)
BIOMOL QuantiZyme™ Assay System
AK-700
CASPASE-3 Enzyme Assay Kit for Drug Discovery
The CASPASE-3 Enzyme Assay Kit for Drug Discovery is a complete assay system to
screen for inhibitors of caspase-3. It employs the colorimetric substrate
DEVD-p-nitroanilide which upon cleavage has increased absorption at 405nm. The assays are
performed in a convenient 96-well microplate format. The kit is useful for high-throughput
screening of caspase-3 inhibitors, a potential therapeutic target8.
An inhibitor, Ac-DEVD-CHO (aldehyde), is also included as a prototypic control inhibitor1.
1 kit (96 well)
1. D.W. Nicholson et al. Nature 1995 376 37
2. T. Fernandes-Alnemri et al. J. Biol. Chem. 1994 269
30761
3. M. Tewari et al. Cell 1995 81 801
4. S.M. Srinivasula et al. Proc. Natl. Acad. Sci. USA 1996 93
14486
5. A.J. Darmon et al. Nature 1995 377 446
6. J. Schlegel et al. J. Biol. Chem. 1996 271 1841
7. Y.A. Lazebnik et al. Proc. Natl. Acad. Sci. USA 1995 92
9042
8. D.W. Nicholson Nature Biotechnol. 1996 14 297
CASPASE-8 ASSAY KIT
BIOMOL QuantiZyme™ Assay System
AK-715
CASPASE-8 Enzyme Assay Kit for Drug Discovery
Caspase-8 (also known as FLICE, MACH and Mch5) is a member of the interleukin-1b converting enzyme (ICE) family
of cysteine proteases. The enzyme is composed of 18 and 11 kDa subunits derived from a
common proenzyme. The N-terminal prodomain of the zymogen comprises two "death
effector domains" homologous to those of FADD (Mort1)1-3. Activation of
the Fas-receptor (Apo-1/CD95) by ligand binding causes FADD to bind to the intracellular
region of the receptor4,5. Pro-caspase-8 binds the receptor-bound FADD,
presumably via interactions between their homologous domains1,2. Binding of the
proenzyme leads to its proteolytic processing and activation by autocatalysis or
interaction with a related caspase (e.g. FLICE2/Mch4)6-8. An event which lies
downstream from caspase-8 activation is proteolytic activation of the caspase-3 proenzyme
through cleavage by caspase-88,9.
The CASPASE-8 Enzyme Assay Kit for Drug Discovery is a complete assay system to
screen for inhibitors of caspase-8. It employs the colorimetric substrate
Ac-IETD-p-nitroanilide which upon cleavage has increased absorption at 405nm. The peptide
sequence IETD is based on the procaspase-3 site of cleavage by caspase-8, and is cleaved
efficiently by caspase-810. The assays are performed in a convenient,
96-well microplate format. The kit is useful for high-throughput screening of caspase-8
inhibitors, a potential therapeutic target. A peptide aldehyde inhibitor is included for
use as a prototypic inhibitor control.
1 kit (96 well)
1. M.P. Boldin et al. Cell 1996 85 803
2. M. Muzio et al. Cell 1996 85 817
3. T. Fernandes-Alnemri et al. Proc. Natl. Acad. Sci. USA 1996 93 7464
4. M.P. Boldin et al. J. Biol. Chem. 1995 270 7795
5. A.M. Chinnaiyan et al. Cell 1995 81 505
6. J. P. Medema et al. EMBO J. 1997 16 2794
7. C. Vincenz and V.M. Dixit J. Biol. Chem. 1997 272 6578
8. S.M. Srinivasula et al. Proc. Natl. Acad. Sci. USA 1996 93 14486
9. M. Muzio et al. J. Biol. Chem. 1997 272 2952
10. N.A. Thornberry et .al. J. Biol. Chem. 1997 272 17907
SUBSTRATES AND INHIBITOR FOR CASPASE-8 AND OTHER CASPASES
The activation of caspase-8 from the proenzyme leads to downstream events including
cleavage of pro-caspase-3 to the active enzyme. The cleavage site in pro-caspase-3 is the
IETD sequence. The following peptides are substrates and aldehyde inhibitor based on the
native cleavage sequence of pro-capsase-3.
P-432
Ac-IETD-AMC, fluorogenic substrate
N-acetyl-Ile-Glu-Thr-Asp-AMC (7-amino-4-methylcoumarin)
Fluorogenic substrate for caspase-6 (Mch2) and -8 (FLICE), and related cysteine proteases.
Ex.: 380nm Em.: 460nm.
5mg
5 x 5mg
P-431
Ac-IETD-pNA, colorimetric substrate
N-acetyl-Ile-Glu-Thr-Asp-pNA (p-nitroanilide)
Similar to P-432 but cleavage is monitored colorimetrically by absorbance at 405nm.
5mg
5 x 5mg
P-430
Ac-IETD-CHO, inhibitor
N-acetyl-Ile-Glu-Thr-Asp-CHO (aldehyde)
Highly potent and reversible inhibitor of caspase-6 (Mch2) and -8, and related cysteine
proteases.
1mg
5 x 1mg
S.M. Srinivasula et al. Proc. Natl. Acad. Sci. USA 1996 93 14486
E.S. Alnemri et al. Cell 1996 87 171
N.A. Thornberry et al. J. Biol. Chem. 1997 272 17907
POLY(ADP-RIBOSE)
SA-276
Anti-poly(ADP-ribose), rabbit polyclonal antibody
This highly sensitive antibody recognizes poly(ADP-ribose) modified proteins and
free polymer, minimum subunit length of 8. Recognition is not species-dependent and there
is no cross-reaction with RNA, DNA, monomers of ADP-ribose and NAD. Applications include
Western blotting (1/1000 dilution using alkaline phosphatase/BCIP/NBT), immunofluorescence
(1/200 dilution), and ELISA. Supplied as serum containing sodium azide.
100µl
SW-108
Automodified PARP, immunoblotting standard
Partially purified poly(ADP-ribose) polymerase (PARP) enzyme, catalog #SE-165,
poly(ADP-ribose) automodified by the addition of NAD and necessary cofactors. Supplied in
SDS-PAGE sample buffer, ready-to-use. A streak of MW>116 kDa is detected by Western
blotting, which represents PARP poly-ADP-ribosylated to various levels. Recommended usage
is 5-20 µl per lane. Storage: -20°C.
100µl
F. Simonin et al. Anal. Biochem. 1991 195 226
G.M. Shah et al. Anal. Biochem. 1995 227 1
G.M. Shah et al. Anal. Biochem. 1995 232 251
SW-110
Mouse Thymus Extract, immunoblotting standard
Whole thymus extract from mouse. Supplied as tissue extract in SDS-PAGE sample
buffer, ready-to-use. Useful as a Western blotting control for anti-poly (ADP-ribose)
polymerase (PARP) antibodies (BIOMOL catalog #SA-250 and SA-252), or for use with other
antibodies/proteins. Use approximately 5 µl sample per lane for SDS-PAGE. Storage: -20°C
200µl
GENE REGULATION
p53 TUMOR SUPPRESSOR
The p53 gene product is a tumor suppressor, and mutations in the p53 gene are involved
in over one-half of human tumors. Null mice in p53 frequently develop tumors, and
reconstitution of its native activity suppresses the growth of tumor cells through
cell-cycle arrest and apoptosis. The p53 tumor suppression mechanism is through active
transcription of specific genes carrying p53 DNA binding motifs. The DNA binding is
allosterically regulated in p53 C-terminal domain, and mutations in this region prevent
gene activation1,2. C-terminal mutations are rescued by injection of anti-p53
monoclonal antibody Pab4213 which recognizes and binds to this region, and by
certain C-terminal synthetic peptides1,2.
P-603
p53 activator (fusion peptide 46), cell permeable
A peptide corresponding to the single-strand DNA end binding site of p53 (residues
361-382; named peptide 46) 1,2 is an activator of wild-type and certain p53
mutants. This peptide is a fusion of peptide 46 linked to the third helix of Drosophila
Antennapedia homeodomain protein sequence to confer cell permeability4,5.
The p53 activator (fusion peptide 46) rescued p53 growth inhibition function (5 µg/ml)
in human osteosarcoma Saos-2 subline transfected with His-273 p53 mutant; induced 56%
apoptosis in Burkitt lymphoma cell line Ew36 carrying wt p53 in 24 h at 20 µM; and in
mutant p53 cell lines BL41 (20%) and SW480 (25%); but has no effect in p53 null cell lines
HL60 and Saos-21. This is a novel, useful tool to study p53 with the potential
to be an anti-tumor lead compound.
0.5mg
5 X 0.5mg
SA-293
Anti-p53, Clone PAb421, mouse monoclonal antibody
The epitope for PAb421 is the C-terminal region of p53, and is contained within
the P-603 peptide, above. Thus the antibody recognizes this peptide and has been used to
examine cellular uptake of the p53 activator peptide1. The PAb antibody also
induces allosteric changes in certain tumor-derived p53 mutants and restores tumor
suppressor activity. Microinjection of PAb421 into SW480 colorectal carcinoma cells
restores transcription activational function to the resident mutant p53 (Arg to His 273,
Pro to Ser 309)3. Immunogen is p53 protein, epitope is human p53 (371-380).
Crossreacts with rat and mouse. Other applications are WB 10 µg/ml, IH, IF and IP.
Supplied as purified IgG2a.
100µg
1. G. Selivanova et al. Nature Medicine 1997 3 632
2. G. Selivanova et al. Nucleic Acids Res. 1996 24 3560
3. P. Abarzua et al. Cancer Res. 1995 55 3490 pab421
4. J. Brugidou et al. Biochem. Biophys. Res. Commun. 1995 214 685
5. D. Derossi et al. J. Biol. Chem. 1994 269 10444
EI-278
BAY 11-7082
(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
99%, MW=207.3 [195462-67-7] Storage: RT
Inhibitor of cytokine-induced IkB-a phosphorylation. Inhibited NF-kB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8,
in TNFa treated
HUVECs, with IC50’s of 5-10 µM. The inhibition of IkB-a phosphorylation and cell adhesion molecule expression and the
stabilization of IkB-a were found to be irreversible
effects1.
10mg
50mg
EI-279
BAY 11-7085
(E)-3-[(4-t-Butylphenylsulfonyl]-2-propenenitrile
99%, MW=207.3 Storage: RT
Inhibited NF-kB
activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8, in TNFa treated HUVECs, with IC50’s
of 5-10 µM. The inhibition of IkB-a phosphorylation and cell adhesion molecule expression and the
stabilization of IkB-a were found to be
irreversible effects. Compound displayed anti-inflammatory activity in two rat model
systems (20 mg/kg i.p.)1.
10mg
50mg
1. J.W. Pierce et al. J. Biol. Chem. 1997 272
21096
PROTEIN PHOSPHORYLATION
EI-282
U-0126
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
98%, MW=380.5 [109511-58-2] Storage: RT
A novel, potent and selective MAP kinase kinase (MEK)
inhibitor, MEK1 IC50=72 nM, MEK2 IC50=58 nM. Has no effect on the kinase activity of PKC,
Abl, Raf, MEKK, ERK, JNK, MKK3, MKK6, Cdk2 and Cdk41. Inhibits T
cell proliferation in response to antigens, representing a new class of immunomodulator2.
1 mg
5 mg
1. M.F. Favata et al. J. Biol. Chem. 1998 273
18623
2. D.R. DeSilva et al. J. Immunol. 1998 160 4175
AK-111
BIOMOL GREEN™ Reagent for phosphate detection
The BIOMOL GREEN™ Reagent is a convenient, 1-step reagent for measuring
the free phosphate released during enzymatic phosphatase assays. It is a modification of
the classic Malachite green reagent 1,2.
250ml
1. B. Martin et al. J. Biol. Chem. 1985 260
14932
2. K.W. Harder et al. Biochem. J. 1994 298 395
AK-804
BIOMOL GREEN™ CALCINEURIN ASSAY KIT
Colorimetric assay kit for measuring Calcineurin phosphatase activity. A convenient
96-well microplate format, with all reagents necessary for measuring calcineurin (PP2B)
phosphatase activity of purified enzyme. The RII phosphopeptide substrate, supplied with
this kit, is the most efficient and outstanding peptide substrate known for calcineurin 1,2.
1. A. Enz et al. Anal. Biochem. 1994 216
147
2. A. Donella-Deana et al. Eur. J. Biochem. 1994 219 109
1 Kit
AK-812
BIOMOL GREEN™ CD45 ASSAY KIT
Colorimetric assay kit for measuring CD45 tyrosine phosphatase activity. A convenient
96-well microplate format, with all reagents necessary for measuring CD45 tyrosine
phosphatase activity of purified enzyme. The pp60c-src negative
regulatory phosphopeptide substrate, supplied with this kit, is an efficient and relevant
peptide substrate for CD45.
1 Kit
SE-333
VHR, Dual-specificity phosphatase (human, recombinant)
MW=20.4 kDa. Human VHR (VH1-Related) dual-specificity phosphatase, expressed in E.
coli. Useful to study VHR dual phosphatase kinetics and substrate specificity, and to
dephosphorylate pSer/Thr and pTyr phosphorylated protein substrates.
50 µg
SE-331
Stp1, low MW phosphatase (S. pombe, recombinant)
MW=17.4 kDa. Yeast (Schizosaccharomyces pombe) stp1+ small
tyrosine phosphatase, expressed in E. coli. Possess phosphotyrosine and
phosphoserine phosphatase activity. Both phosphatase activities are inhibited by 1 mM
vanadate. Also can hydrolyse FMN. Useful to study dual phosphatase kinetics and substrate
specificity.
50 µg
SE-332
PTP1B, protein tyrosine phosphatase (human,
recombinant)
MW=37.4 kDa. Human protein tyrosine phosphatase (residues 1-322), expressed in E.
coli. PTP1B is the ubiquitous, prototype nontransmembrane PTP originaly identified in
human placenta. Useful to study tyrosine phosphatase kinetics and substrate specificity.
50 µg
SE-330
Yop51*/D162, PTPase (Yersinia enterocolitica,
recombinant)
MW=33.5 kDa. Yersinia enterocolitica yop51 gene with N-terminal truncation,
plus point mutation 235 Cys to Arg to increase protein expression. The protein (residues
163-468) contains the entire tyrosine phosphatase catalytic domain, and is expressed in E.
coli. Useful to remove phosphate specifically from tyrosine residues in proteins, and
to study enzyme/inhibitor interactions.
50 µg
NITRIC OXIDE SYNTHASE
SA-227
Anti-bNOS (NOS1), rabbit polyclonal antibody.
This is a new, highly specific antibody for brain NOS. It was produced using human
brain NOS (NOS1) synthetic peptide (amino acids 1414-1434). The antibody reacts
specifically with 155 kDa brain nitric oxide synthase (NOS1) from human, rat and mouse.
There is no cross-reactivity to iNOS or eNOS. It is useful for immunological methods
including WB,IF,ELISA. Supplied as protein A purified IgG.
100µg
SK-002
Anti-bNOS (NOS1) KIT
This kit will facilitate your research and is economical! It includes the
following components:
25 µg of the SA-227 antibody; 100 µg of control blocking peptide (SP-227); 200 µl purified rat bNOS, ready-to-use for SDS-PAGE (SW-109); 200 µl mouse brain extract standard,
ready-to-use for SDS-PAGE (SW-104); Instructions for use in Western blotting.
1 Kit
SP-227
Control peptide for SA-227
Purity >95%; Supplied at 1 mg/ml.
This peptide is the hapten used to produce the SA-227 polyclonal antibody. Princubation of
the peptide with antibody will effectively block specific immunostaining of experimental
samples. This allows discrimination between staining due to the presence of bNOS versus
non-specific factors.
100µg
SW-103
Rat brain extract, immunoblotting standard
Whole brain extract from rat. Use approximately 5 µl (~25 µg) per SDS-PAGE lane.
200µl
SW-104
Mouse brain extract, immunoblotting standard
Whole brain extract from mouse. Use approximately 5 µl (~25 µg) per SDS-PAGE
lane.
200µl
SW-109
Rat recombinant bNOS standard
This is purified rat recombinant bNOS which can be used as a SA-227 positive
control. It is ready-to-use for SDS-PAGE. Detection limit is <10 ng by alkaline
phosphatase/BCIP/NBT detection. Supplied in SDS-PAGE sample buffer, 2 µg/ml.
100µl
V. Riveros-Moreno et al. Eur. J. Biochem. 1993 215 801
D.R. Springall et al. Biochemistry 1992 98 259
CN-267
4-Amino-(6R)-tetrahydro-L-biopterin
Exhibits a 20-fold higher affinity (Ki for competitive binding=13.2 nM)
for rat neuronal NOS than the natural cofactor 6R-H4biopterin. Strongly
inhibits the stimulation of NOS enzymatic activity by 6R-H4biopterin (IC50=1
µM).
10mg
50mg
E.R. Werner et al. Biochem. J. 1996 320 193
CELL CYCLE
CC-210
Butyrolactone I
99%, MW=424.5, Storage:-20°C
Butyrolactone I, a compound isolated from an Aspergillus species, is a highly
selective inhibitor of CDKs. CDKs are inhibited at low µM concentrations (for cyclin
B-cdc2, IC50 = 0.68 µM), while a wide range of other kinases are at least
100-fold less sensitive (kinase/IC50(µM): MAPK/94; PKC/160; PKA/260; CKII/240;
CKI/>590; EGFR/>590)1. Other CDKs shown to be sensitive to butyrolactone
I are cdk21 and cdk52.
Butyrolactone I is cell permeable. G1/S and G2/M transitions, in
WI38 cells, were inhibited by butyrolactone I, concurrent with inhibition of the
phosphorylations of, respectively, retinoblastoma protein and histone H13.
Butyrolactone I blocks Fas-induced apoptosis in HL60 cells, apparently via inhibition of
cdc24. Also, apparently due to cdc2 inhibition, are its anti-tumor effects on
human lung cancer cell lines, including those with multidrug- and cisplatin-resistant
phenotypes5.
1 mg
1. M. Kitagawa et al. Oncogene 1993 8 2425
2. T. Hosoi et al. J. Biochem. Tokyo 1995 117 741
3. M. Kitagawa et al. Oncogene 1994 9 2549
4. Y. Furukawa et al. J. Biol. Chem. 1996 271 28469
5. K. Nishio et al. Anticancer Res. 1996 16 3387
CYTOSKELETON
T-119
Latrunculin A
Purity: 98%, MW=421.6 Storage: -20°C
Latrunculin A is a structurally unique marine toxin isolated from the Red Sea sponge Latrunculia
magnifica. It inhibits actin polymerization in vitro1 and disrupts
microfilament organization2 in vivo in cultured cells in a reversible
manner. The mechanism of latrunculin A action is by sequestering actin monomers, and
differs from cytochalasin B and D3. Induces aggregation of rabbit
polymorphonuclear leukocytes in a dose- and time-dependent manner (12-60 nM)4.
Completely disrupts yeast actin cytoskeleton within 2-5 min5. Latrunculin A is
a powerful new tool to complement the cytochalasins for the study of the mechanisms
underlying actin polymerization in vitro and microfilament organization and
function in living cells.
1. I. Spector et al. Science 1983 219 493
2. I. Spector et al. Cell Motil. Cytoskeleton 1989 13 127
3. F. Braet et al. Hepatology 1996 24 627
4. C.A. Oliveira et al. Life Sci. 1997 61 603
5. K.R. Ayscough et al. J. Cell. Biol. 1997 137 399
ANGIOGENESIS INHIBITORS
AM-100
Cyclo [Arg-Gly-Asp-D-Phe-Val]
98%, MW=661.7 Storage: -20°C
Integrin avb3
antagonist. Inhibits cell adhesion events mediated by avb31. Inhibits angiogenesis. Induces rapid regression of
histologically distinct human tumors2.
1 mg
5 x 1 mg
1. M. Aumailley et al. FEBS Lett. 1991 291 50
2. P.C. Brooks et al. Cell 1994 79 1157
CT-100
Fumagillin
95%, MW=458.6 [23110-15-8] Storage: -20°C
Inhibits angiogenesis1 and endothelial cell proliferation2. Exhibits
antitumor activity in estrogen-induced pituitary adenoma3. Covalently binds to
and inhibits the methionine aminopeptidase, MetAP-24.
1 mg
5 x 1 mg
1. D. Ingber et al. Nature 1990 348 555
2. M. Kusaka et al. Biochem. Biophys. Res. Commun. 1991 174 1070
3. H. Stepien et al. J. Endocrinol. 1996 150 99
4. N. Sin et al. Proc. Natl. Acad. Sci. USA 1997 94 6099
S-540
2-Methoxyestradiol
95%, MW=302.4 [362-07-2] Storage: RT
An endogenous estrogen metabolite with low affinity for the estrogen receptor but which
disrupts microtubule function. Potent inhibitor of endothelial cell proliferation and
migration1. Inhibits bFGF and VEGF-induced corneal neovascularization in mice2.
10 mg
50 mg
1. T. Fotsis et al. Nature 1994 368 237
2. N. Klauber et al. Cancer. Res. 1997 57 81
CT-105
Ursolic acid
95%, MW=456.7 [77-52-1] Storage: -20°C
Inhibits endothelial cell proliferation and migration (IC50=5 µM) and
angiogenesis1.
50 mg
250 mg
1. K.H. Sohn et al. Cancer Lett. 1995 94 213
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