TWC BioSearch
Molecular Biology Links
General Resources and Tools for
the Researcher
Calculators
Online - Links to a huge number of interactive calculators, from chemistry
and engineering to agriculture and statistics. Useful entries include a
DNA/RNA
concentration calculator and a PCR
primer design calculator.
Medline Workbench
- Search Evaluated Medline, PubMed or AbstractsFinder all from the same
page. You can also sign up to receive a free daily update of your PubMed
queries via e-mail and get access to a number of free online journals.
Molecular
Biology Notebook Online - An excellent collection of course materials
for the teaching of Molecular Biology. Designed primarily for undergraduates.
NIH
Office of Extramural Research - Stats and information about NIH grants,
as well as a searchable database (CRISP) of federally supported research
projects.
WebElements Periodic
Table - An interactive periodic table. Includes a short background
and description, along with uses, electronic properties, physical properties,
and crystal structures for each element. There are even nerdy science cartoons
and a few short movies.
General Life Science Resources
Art's
Biotech Resources - An outstanding metalist of molecular biology, biochemistry,
biophysics and bioinformatics sites. Includes links to protocols, tutorials,
software and databases.
BioChemNet
- A list of biology and chemistry educational resources.
Biocrawler -
A life science search engine, with links to current life science news.
Biology
Links - An extensive list of links to biochemistry, molecular biology
and immunology resources from the Harvard University Dept of Molecular
and Cellular Biology.
Buffers
Introduction - Includes a a detailed discussion of buffers and buffer
theory, as well as a useful application that generates buffer recipes based
on your input parameters.
Cell & Molecular
Biology Online - An annotated metalist of resources for molecular and
cellular biologists. Includes links to protocols, codon usage and periodic
tables, and education resources.
DNA Learning Center
- An excellent educational resource, geared toward students and nonscientists,
for information about genes. Check out DNA
From the Beginning, an animated primer on the basics of DNA, genes
and heredity.
Indiana University
Bio Archive - A collection of software (free!) and data for molecular
biology and related areas.
The National Biotechnology
Information Facility (NBIF) - A dizzying number of links to research
tools and databases related to the life sciences.
National Center
for Biotechnology Information (NCBI) - A national resource for molecular
biology information from the National Library of Medicine and NIH. This
is the home of the popular Entrez databases. You can search PubMed, submit
your sequence to GenBank, perform BLAST searches and get genome information
on a number of different organisms.
Primer
3 - An interactive, forms-based tool for designing primers from an
input DNA sequence.
The Bio
Sciences Virtual Library - A metalist of resources categorized by life
science field.
Nucleic Acid and Protein Sequence
and Structure Databases
Baylor
College of Medicine Search Launcher - Search multiple databases with
a single input nucleic acid or protein sequence. You can also get secondary
structure predictions based on sequences.
Molecules
R Us Utility - A searchable PDB database of protein and nucleic acid
structures.
Nucleic
Acid Database - An X-ray structure database of nucleic acids and nucleic
acid-containing structures. Includes an interface to search nucleic acid-containing
NMR structures.
Protein
Data Bank - A searchable database of 3-D macromolecular structures.
Single Nucleotide Polymorphisms
for Biomedical Research - A public database of single nucleotide polymorphisms
(SNPs) within the human genome.
Molecular Biology Protocol Collections
and Techniques Forums
Biowire
- A resource for user-written reviews of life science products. Requires
membership (free).
Comprehensive
Protocols Collection - Various molecular biology protocols collected
by the Ambros lab at Dartmouth College.
Molecular
Biology Protocols - A collection of basic protocols on the most popular
molecular biology techniques. From the Northwest Fisheries Science Center.
Molecular
Biology Techniques Forum - A forum for reader-submitted techniques,
tips and questions concerning molecular biology. Run by the Northwest Fisheries
Science Center.
PCR
and Multiplex PCR: Guide and Troubleshooting - A very informative guide
to PCR, including discussions of parameters influencing PCR, troubleshooting
advice and PCR applications. Also includes links to a discussion of FISH
(fluorescent in situ hybridization) and CCK (color changing karyotyping).
The Polymerase
Chain Reaction (PCR) Jump Station - Bills itself as "the ultimate Web
page for information and links on all aspects of the Polymerase Chain Reaction
(PCR)," which is actually a pretty good description of its offerings.
Protocols
for Recombinant DNA Isolation, Cloning and Sequencing - An extensive
protocol collection of common methods (mostly DNA related) used in molecular
biology laboratories. The appendix
contains useful information tidbits, such as units and formulas, DNA mobility
in gels and consensus sequences in nucleic acids. From Bruce Roe's lab
at the University of Oklahoma.
Science
Exchange Protocols - A collection of molecular biology, molecular immunology,
immunochemistry and immunology protocols submitted from researchers around
the world.
RNA Related Resources
RNA
- The official journal of the RNA Society.
RNA
Analysis Tools - A list of tools to predict RNA secondary structure,
as well as distances, specific heat and energy of RNA secondary structures.
RNA
Editing Web Site - A wealth of information on all the various types
of RNA editing. Includes a bulletin board and links to related Web sites,
databases and jobs available.
The RNA Society
- A FASEB organization. Get information about the RNA Society annual
meeting and upcoming events.
Free
Energy and Enthalpy Tables for RNA Folding - A collection of tools
and tables for estimating the free energies of various RNA secondary structures.
From D.H. Turner's lab at the University of Rochester.
Nylon
MicroArrays - A good introduction to cDNA microarrays and macroarrays,
which are used to measure gene expression levels.
The RNA
Modifications Database - A comprehensive listing of post-transcriptionally
modified nucleosides from RNA.
The RNA World
at IMB-Jena - Perhaps the best metalist of RNA related topics on the
Web. Includes links to structure and sequence databases, protocols, software
and tutorials.
TRANSFAC
(The Transcription Factor Database) - Information on transcription
factors, such as classifications, recognition sequences, amino acid sequences
and references. You can search for transcription factor recognition sites
in your DNA sequences.
RNA Clubs
Bay
Area RNA Club - San Francisco, CA.
Cambridge
University RNA Club - Cambridge, UK.
Great
Lakes RNA Club - Wayne State University, Detroit, MI.
NC
State RNA Biology Group - Raleigh, NC.
The
RNA Interest Group - The NIH RNA club.
Scottish
RNA Club - Scotland.
University of
Texas RNA Club - Austin, TX.
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