SIGNAL TRANSDUCTION RESEARCH
 
 

http://www.cellsignal.com  Cell Signaling Technology (CST) has tools for Signal Transduction and Drug discovery. It was formerly the Signal Transduction wing of New England Biolabs (http://www.neb.com). This Signal Transduction wing grew so much that the company divided like a bacteria cell into two daughter companies.

 

• Pathway Diagrams 
• Protein Domains
• Protocols
• Alternative Names for Cell Signaling Technologies Products
• Using Peptide Libraries to Determine Kinase Substrate Specificity 
• http://www.biomol.com  Signal Transduction biochemical reagents
• http://www.scbt.com Low cost Signal Transduction Antibodies
• http://www.stke.org signal transduction knowledge environment: resources and information on signal transduction, Science Magazine and Stanford University
• http://www.sdsc.edu/projects/Kinases/pk_home.html Protein Kinase Resource: the genetics, enzymology, and molecular properties of protein kinases, University of California San Diego
• http://www.copewithcytokines.de/cope.cgi?001441 cytokines online encyclopedia, University of Munich
• http://cytokine.medic.kumamoto-u.ac.jp/ a database of Expressed Sequence Tag records of cytokine cDNAs, Kumamoto University
• http://www.gpcr.org/7tm/ information system for G protein-coupled receptors
• http://www.cbs.dtu.dk/databases/PhosphoBase/ a database of protein phosphorylation sites
• http://www2.stanford.edu/~rnusse/wntwindow.html the Wnt gene homepage
• http://ycmi.med.yale.edu/senselab/ordb/ olfactory receptor database, Yale University
• http://www.gcrdb.uthscsa.edu/ the G-protein-coupled Receptor Database, University of Texas Health Center at San Antonio
• http://bioinformatics.weizmann.ac.il/hotmolecbase/hotmolec.htm resource contains extensive annotations of ‘hot molecules?that may play crucial roles in common diseases, Weizmann Institute
• http://geo.nihs.go.jp/csndb/ cell signaling networks database for human cells; pathways are interactively represented by computerized graphics, National Institute of Health Sciences, Japan
• http://www.csa.ru/Inst/gorb_dep/inbios/genet/genet.htm interactive graphical representations of regulatory gene networks acting at embryogenesis

ANTIBODY RESOURCES

www.antibodyresource.com outstanding clearinghouse for locating specific antibodies and immunology resources

http://www.pebio.com/pa/340913/340913.html a practical guide to the production of anti-peptide antibodies

http://www.atcc.org/ ATCC catalog of cell lines including hybridomas that produce a broad spectrum of antibodies

PROTEOMIC/GENOMIC TOOLS

http://www.expasy.ch/ outstanding proteomic and genomic databases and tools from the Swiss Bioinformatics Institute, home of
Swiss Prot

http://workbench.sdsc.edu Biology Workbench, an integrated search, modeling and analysis platform that accesses all major protein and nucleic acid databases, University of Illinois

http://www.ncbi.nlm.nih.gov/Genbank/GenbankOverview.html GenBank, an annotated database of all publicly available DNA sequences, N.I.H.N.L.M.

http://www.ncbi.nlm.nih.gov/BLAST/blast_overview.html  BLAST (Basic Local Alignment Search Tool), a set of search programs for identifying sequence similarities between protein and nucleotide sequences, N.I.H.N.L.M.

http://pfam.wustl.edu/hmmsearch.shtml tool for analyzing the domain structure of protein sequences, PFAM consortium: Sanger Centre, Washington University, Karolinska Institute

http://genome.wustl.edu/gsc/ Genome Sequencing Center, Washington University

http://bioinfo.weizmann.ac.il/cards/ GeneCards: a database of human genes, their products and their involvement in disease, Weizmann Institute

http://web.wi.mit.edu/bio/pub/biopage2.html links to molecular sequence analysis tools for nucleotides and proteins, Whitehead Institute

http://www.genome.ad.jp/kegg/ computerized effort to model molecular interactions, Kyoto University

http://www.kazusa.or.jp/huge/index.html sequence database of long (>4 kb) human cDNAs, Kazusa DNA Research Institute

http://www.mips.biochem.mpg.de/ genomic sequences and tools, Max-Planck-Institut f. Biochemie Munich

 

ONLINE PUBLICATIONS AND LITERATURE SEARCH ENGINES

http://www.ncbi.nlm.nih.gov/PubMed/ NLM’s search service to citations in MEDLINE, with links to online journals and other related databases, N.I.H.

http://www.pubcrawler.ie/ a free "alerting" service that scans daily updates to the NCBI Medline and GenBank databases

http://www.geocities.com/~jrbeasley/biochem/journals.html biochemistry, molecular and cellular biology journals online

DISEASE AND MUTATION DATABASES

http://www4.ncbi.nlm.nih.gov/omim/ Online Mendelian Inheritance in Man: catalog of human genes and genetic disorders, N.I.H.

http://www.angis.su.oz.au/Databases/BIRX/omia/ Online Mendelian Inheritance in Animals: catalog of animal genes and genetic disorders, University of Sydney

http://www4.ncbi.nlm.nih.gov/Omim/Index/mutation.html links to a number of locus specific mutation databases, N.I.H.

http://www.uta.fi/imt/bioinfo/KinMutBase/ database of disease-causing mutations in tyrosine kinase domains, links to other mutation databases, University of Tampere

http://www.ncbi.nlm.nih.gov/Disease_Genes/m97hdt0.html positionally cloned human disease genes, N.I.H.

http://www.ncbi.nlm.nih.gov/ncicgap/ Cancer Genome Anatomy Project: database of the genes responsible for cancer, N.I.H.

http://www.fruitfly.org/sequence/human2fly.html sequence similarities of human inherited disease genes with drosophila DNA

KNOCKOUT AND TRANSGENIC MICE

http://www.bioscience.org/knockout/knochome.htm list of those genes which have been ablated in mice and the phenotypic effects of these knockouts

http://www.ornl.gov/TechResources/Trans/hmepg.html transgenic and targeted mutant animal database, Oak Ridge National Laboratory

http://jaxmice.jax.org/html/pricelist/induced.shtml source of mice with induced mutations, The Jackson Laboratory

GENOME DATABASES

http://www.gdb.org/gdb/ Human Genome Project database, Toronto

http://www.sanger.ac.uk/HGP/ the human genomic research program, Sanger Center

http://www.tigr.org/tdb/hgi/searching/hgi_reports.html TIGR human gene index

http://www.gen.emory.edu/mitomap.html human mitochondrial genome, Emory University

http://www.informatics.jax.org/ the mouse genome, Jackson Laboratory

http://www.fruitfly.org/ drosophila genome project, Berkeley

http://www.sanger.ac.uk/Projects/C_elegans/ the C. elegans genome, Sanger Center

http://genome-www.stanford.edu/Saccharomyces/ the S. cerevisiae genome, Stanford

http://www.mips.biochem.mpg.de/proj/yeast/ the S. cerevisiae genome, Munich

http://pbil.univ-lyon1.fr/emglib/emglib.html completely sequenced bacterial genomes and the yeast genome, Universite Claude Bernard, Lyon

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